Augmented Passive Immunotherapy with P4 Peptide Improves Phagocyte Activity in Severe Sepsis
نویسندگان
چکیده
منابع مشابه
Passive immunotherapy of sepsis with intravenous immune globulin: not all IVIg preparations are created equal
are known to neutralize a wide array of pathogens plus their virulence factors and in addition possess broad antiinfl ammatory and immunomodulating activities. However, these preparations have not been really successful in their present form in preventing sepsis-related death. Th e recent report by the International Neonatal Immunotherapy Study Collaborative Group is the account of the last in ...
متن کاملPeptide presentation by bacteriophage P4.
This article focuses on bacteriophage P4 as a potential peptide display phage by exploring the possibility of using the P4 capsid decoration component, Psu, as a peptide carrier protein. Psu is non-essential for P4 growth but it enhances the stability of the P4 capsid by binding to its exterior. We have constructed a unique SacI cloning site in the beginning of the psu gene. This site changes t...
متن کاملPassive leg raising as an indicator of fluid responsiveness in patients with severe sepsis.
BACKGROUND In the management of critically ill patients, the assessment of volume responsiveness and the decision to administer a fluid bolus constitute a common dilemma for physicians. Static indices of cardiac preload are poor predictors of volume responsiveness. Passive leg raising (PLR) mimics an endogenous volume expansion (VE) that can be used to predict fluid responsiveness. This study w...
متن کاملPassive Immunotherapy Protects against Enteric Invasion and Lethal Sepsis in a Murine Model of Gastrointestinal Anthrax
The principal portal for anthrax infection in natural animal outbreaks is the digestive tract. Enteric exposure to anthrax, which is difficult to detect or prevent in a timely manner, could be exploited as an act of terror through contamination of human or animal food. Our group has developed a novel animal model of gastrointestinal (GI) anthrax for evaluation of disease pathogenesis and experi...
متن کاملRecombinant human soluble thrombomodulin improves mortality and respiratory dysfunction in patients with severe sepsis.
BACKGROUND Respiratory dysfunction associated with severe sepsis is a serious condition leading to poor prognosis. Activation of coagulation is a consequence of and contributor to ongoing lung injury in severe sepsis. The purpose of this study was to examine the efficacy of recombinant human soluble thrombomodulin (rhTM), a novel anticoagulant agent, for treating patients with sepsis-induced di...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Shock
سال: 2016
ISSN: 1073-2322
DOI: 10.1097/shk.0000000000000715